Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.50 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.50 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6840328 | 0.80 | ACHE (0.54) | ALOX5EPHX2MEN1KMT2AMAPT | |
| SCHEMBL8777890 | 0.80 | BRD4 (0.45) | ALOX5EPHX2KCNT1 | |
| SCHEMBL7710166 | 0.79 | ALOX5 (0.53) | ALOX5EPHX2ALDH1A1GAA | |
| SCHEMBL8778007 | 0.78 | LMNA (0.50) | ALOX5EPHX2TP53THRBLMNA | |
| SCHEMBL16494808 | 0.78 | ACHE (0.62) | ALOX5EPHX2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL9088740 | 0.78 | ALOX5 (0.46) | ALOX5EPHX2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL16494841 | 0.77 | ACHE (0.56) | ALOX5EPHX2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL8778095 | 0.77 | FFAR1 (0.47) | ALOX5EPHX2TP53LMNAPOLB | |
| SCHEMBL16494169 | 0.77 | ACHE (0.56) | ALOX5EPHX2TP53THRBMAPT | |
| SCHEMBL697874 | 0.77 | ALOX5 (0.56) | ALOX5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |