Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597479 | 0.84 | KEAP1 (0.46) | KEAP1SIRT2SIRT1PTGER4PTGER2 | |
| SCHEMBL9597655 | 0.83 | KEAP1 (0.43) | KEAP1SIRT2SIRT1PTGER4PTGER2 | |
| SCHEMBL8777919 | 0.83 | KEAP1 (0.49) | KEAP1SIRT2SIRT1PTGER4PTGER2 | |
| SCHEMBL5082657 | 0.82 | PTGER4 (0.48) | KEAP1SIRT2SIRT1PTGER4PTGER2 | |
| SCHEMBL9597102 | 0.81 | PTGER4 (0.43) | SIRT2SIRT1PTGER4PTGER2KMT2A | |
| SCHEMBL9597204 | 0.80 | HDAC1 (0.45) | SIRT2SIRT1PTGER4PTGER2KMT2A | |
| SCHEMBL9597631 | 0.80 | PTGER4 (0.43) | KEAP1SIRT2SIRT1PTGER4PTGER2 | |
| SCHEMBL9597600 | 0.79 | HDAC1 (0.44) | SIRT2SIRT1PTGER4PTGER2KMT2A | |
| SCHEMBL9198265 | 0.78 | HDAC1 (0.51) | SIRT2SIRT1PTGER4PTGER2KMT2A | |
| SCHEMBL9030409 | 0.78 | HDAC1 (0.53) | SIRT2SIRT1PTGER4PTGER2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5541218-A | Indolinyl N-hydroxyurea and N-hydroxamic acid derivatives as lipoxygenase inhibitors | PFIZER INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0651743-A1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1995-05-10 | — | — | EP | disclosed |
| CN-1085894-A | The indolinyl N-hydroxyurea of anti-inflammatory and N-hydroxamic acid derivs | PFIZER (US) | 1994-04-27 | — | — | CN | disclosed |
| WO-1994002459-A1 | INDOLINYL N-HYDROZYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-02-03 | — | — | WO | disclosed |