Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777934 | 0.83 | KEAP1 (0.51) | KEAP1SIRT2SIRT1PTGER4PTGER2 | |
| SCHEMBL4728356 | 0.82 | MAPT (0.51) | SIRT2SIRT1PTGER4PTGER2KMT2A | |
| SCHEMBL8245692 | 0.74 | ALDH1A1 (0.68) | KMT2AMEN1 | |
| SCHEMBL30104666 | 0.74 | ALDH1A1 (0.68) | KMT2AMEN1 | |
| SCHEMBL8778025 | 0.72 | PTGER4 (0.52) | PTGER4PTGER2PKM | |
| SCHEMBL8777878 | 0.72 | KEAP1 (0.45) | KEAP1SIRT2SIRT1PTGER4PTGER2 | |
| SCHEMBL29572755 | 0.71 | SIGMAR1 (0.57) | SIRT2SIRT1PTGER4PTGER2KMT2A | |
| SCHEMBL5661589 | 0.71 | SIGMAR1 (0.57) | SIRT2SIRT1PTGER4PTGER2KMT2A | |
| SCHEMBL8778079 | 0.71 | PTGER4 (0.49) | SIRT2SIRT1PTGER4PTGER2KMT2A | |
| SCHEMBL8778095 | 0.71 | FFAR1 (0.47) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |