Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777912 | 0.87 | F10 (0.46) | PPARGPPARAF2RPLK1PLK3 | |
| SCHEMBL8777855 | 0.86 | LMNA (0.38) | F2RPLK1ALDH1A1MAPT | |
| SCHEMBL8777938 | 0.82 | EPHX2 (0.49) | HDAC3HDAC1ALDH1A1MAPT | |
| SCHEMBL8777955 | 0.74 | HDAC1 (0.60) | SOAT1PPARGPPARAPPARDHDAC3 | |
| SCHEMBL8804530 | 0.73 | GAA (0.40) | SOAT1PPARGPPARARBP4HDAC3 | |
| SCHEMBL8803801 | 0.72 | RBP4 (0.39) | RBP4HDAC3HDAC1F2RALDH1A1 | |
| SCHEMBL8803793 | 0.72 | RBP4 (0.39) | RBP4HDAC3HDAC1F2RALDH1A1 | |
| SCHEMBL8778076 | 0.71 | KCNMA1 (0.46) | SOAT1PPARGPPARAALDH1A1MAPT | |
| SCHEMBL8804984 | 0.70 | GAA (0.38) | SOAT1PPARGPPARAPPARDPLK1 | |
| SCHEMBL8777969 | 0.70 | EPHX2 (0.52) | F2RALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |