Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206959 | 0.94 | MAPT (0.49) | MAPTTP53KDM4EMEN1KMT2A | |
| SCHEMBL9597526 | 0.87 | ALDH1A1 (0.51) | MAPTTP53KDM4EMEN1KMT2A | |
| SCHEMBL4728528 | 0.86 | ALOX5 (0.45) | ACHEALOX5 | |
| SCHEMBL8777936 | 0.81 | TP53 (0.52) | MAPTTP53KDM4EMEN1KMT2A | |
| SCHEMBL9029836 | 0.80 | HDAC1 (0.53) | MAPTTP53KDM4EMEN1KMT2A | |
| SCHEMBL9088952 | 0.80 | PTGER4 (0.51) | MAPTALDH1A1GAATDP1MAPK1 | |
| SCHEMBL9088999 | 0.79 | KDM4E (0.45) | KDM4EALDH1A1LMNAGAAHTT | |
| SCHEMBL4784159 | 0.78 | ACHE (0.44) | MAPTTP53ALDH1A1GAACASP1 | |
| SCHEMBL8777973 | 0.77 | PTGER4 (0.46) | KMT2AALOX5PTGER4PTGER2 | |
| SCHEMBL9086492 | 0.77 | BRD4 (0.47) | TP53KDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5541218-A | Indolinyl N-hydroxyurea and N-hydroxamic acid derivatives as lipoxygenase inhibitors | PFIZER INC. (US) | 1996-07-30 | — | — | US | disclosed |
| CN-1085894-A | The indolinyl N-hydroxyurea of anti-inflammatory and N-hydroxamic acid derivs | PFIZER (US) | 1994-04-27 | — | — | CN | disclosed |
| WO-1994002459-A1 | INDOLINYL N-HYDROZYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-02-03 | — | — | WO | disclosed |