Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 17/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777856 | 0.80 | MAPT (0.51) | EPHX2MAPTNPSR1 | |
| SCHEMBL8777892 | 0.79 | EPHX2 (0.48) | EPHX2MAPTNPSR1CNR2 | |
| SCHEMBL8777901 | 0.77 | EPHX2 (0.52) | EPHX2ALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL8777967 | 0.76 | MEN1 (0.35) | TSHRMAPK1NPSR1CNR2 | |
| SCHEMBL8777924 | 0.74 | P2RY1 (0.50) | EPHX2ALDH1A1MAPT | |
| SCHEMBL8803890 | 0.72 | EPHX2 (0.54) | EPHX2TSHRMAPK1RAB9AMAPT | |
| SCHEMBL8804609 | 0.72 | EPHX2 (0.54) | EPHX2MAPK1 | |
| SCHEMBL8803889 | 0.72 | EPHX2 (0.54) | EPHX2TSHRMAPK1RAB9AMAPT | |
| SCHEMBL3891472 | 0.68 | GLA (0.50) | RAB9AALDH1A1NPSR1 | |
| SCHEMBL3900251 | 0.67 | PDE4D (0.60) | RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |