Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.52 |
| ▸ | CNR2 | P34972 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777892 | 0.87 | EPHX2 (0.48) | EPHX2CNR2NPSR1MAPT | |
| SCHEMBL8777856 | 0.84 | MAPT (0.51) | EPHX2NPSR1MAPT | |
| SCHEMBL8777858 | 0.80 | F10 (0.49) | EPHX2MEN1KMT2AF10MAPT | |
| SCHEMBL8777894 | 0.79 | F10 (0.39) | CNR2MEN1KMT2AFAAHF10 | |
| SCHEMBL8777963 | 0.77 | EPHX2 (0.47) | EPHX2CNR2NPSR1MAPTALDH1A1 | |
| SCHEMBL8777941 | 0.76 | F10 (0.43) | MEN1KMT2AF10MAPTLPAR1 | |
| SCHEMBL8777926 | 0.75 | KMT2A (0.63) | MEN1KMT2AF10GAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL8946231 | 0.75 | F10 (0.42) | MEN1KMT2AF10MAPTLPAR1 | |
| SCHEMBL8777906 | 0.74 | F10 (0.47) | EPHX2MEN1KMT2AF10MAPT | |
| SCHEMBL8778117 | 0.74 | F10 (0.47) | EPHX2MEN1KMT2AF10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |