Sugi Predict

Sugi Predict / Compounds / SCHEMBL8777856

SCHEMBL8777856

SCHEMBL8777856

CC(C)(C)c1cc(C(=O)Nc2cc(Cl)c(Cl)cc2NC(=O)NC23CC4CC(CC(C4)C2)C3)cc(C(C)(C)C)c1O

nearest known ligand 0.51

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 1/20 0.51
▸ NPSR1 Q6W5P4 1/20 0.51
▸ EPHX2 P34913 14/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8777892 0.86 EPHX2 (0.48) MAPTNPSR1EPHX2
SCHEMBL8777901 0.84 EPHX2 (0.52) MAPTNPSR1EPHX2
SCHEMBL8777963 0.80 EPHX2 (0.47) MAPTNPSR1EPHX2
SCHEMBL8777850 0.79 HSD11B1 (0.38) MAPTNPSR1EPHX2
SCHEMBL4348756 0.74 NPSR1 (0.55) MAPTNPSR1EPHX2
SCHEMBL8803890 0.72 EPHX2 (0.54) MAPTNPSR1EPHX2
SCHEMBL8803889 0.72 EPHX2 (0.54) MAPTNPSR1EPHX2
SCHEMBL8804609 0.72 EPHX2 (0.54) EPHX2
SCHEMBL4346873 0.72 EPHX2 (0.57) MAPTNPSR1EPHX2
SCHEMBL8778024 0.71 EPHX2 (0.46) MAPTEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0665216-B1 Urea derivatives and their use as acat inhibitors NISSHIN FLOUR MILLING CO (JP) 1997-12-29 — — EP disclosed
US-5576335-A TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS NISSHIN FLOUR MILLING CO., LTD. (JP) 1996-11-19 — — US disclosed
EP-0665216-A1 Urea derivatives and their use as acat inhibitors NISSHIN FLOUR MILLING CO., LTD. (JP) 1995-08-02 — — EP disclosed