Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9086492 | 0.82 | BRD4 (0.47) | BRD4ALDH1A1KDM4ECYP3A4RECQL | |
| SCHEMBL9535250 | 0.81 | HDAC1 (0.49) | MEN1KMT2A | |
| SCHEMBL8778007 | 0.80 | LMNA (0.50) | BRD4ALDH1A1KDM4ECYP3A4RECQL | |
| SCHEMBL29572414 | 0.74 | BRD4 (0.58) | BRD4ALDH1A1KDM4ECYP3A4RECQL | |
| SCHEMBL19428145 | 0.74 | BRD4 (0.58) | BRD4ALDH1A1KDM4ECYP3A4RECQL | |
| SCHEMBL17358767 | 0.74 | BRD4 (0.45) | BRD4ALDH1A1KDM4ECYP3A4RECQL | |
| SCHEMBL16495220 | 0.73 | MAPT (0.46) | BRD4ALDH1A1TNFGFER | |
| SCHEMBL16495267 | 0.72 | MAPT (0.47) | ALDH1A1TNFHTT | |
| Methane SCHEMBL27429811 | 0.70 | TNF (0.46) | BRD4TNF | |
| SCHEMBL14149903 | 0.70 | ALOX5 (0.48) | ALDH1A1KDM4ERECQLMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |