Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | TP53 | P04637 | 6/20 | 0.50 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728356 | 0.86 | MAPT (0.51) | LMNATP53THRBALDH1A1 | |
| SCHEMBL8777898 | 0.84 | MAPT (0.51) | LMNAALOX5EPHX2CYP3A4TDP1 | |
| SCHEMBL8778095 | 0.83 | FFAR1 (0.47) | LMNATP53ALOX5EPHX2KDM4E | |
| SCHEMBL9086492 | 0.82 | BRD4 (0.47) | LMNATP53BRD4KDM4EALDH1A1 | |
| SCHEMBL8778009 | 0.80 | BRD4 (0.47) | BRD4KDM4EALDH1A1CYP3A4RECQL | |
| SCHEMBL8777937 | 0.78 | ALOX5 (0.55) | LMNATP53THRBALOX5EPHX2 | |
| SCHEMBL5527522 | 0.78 | KDM4E (0.61) | TP53KDM4EALDH1A1RECQLTDP1 | |
| SCHEMBL8777936 | 0.77 | TP53 (0.52) | LMNATP53THRBALOX5EPHX2 | |
| SCHEMBL8778025 | 0.76 | PTGER4 (0.52) | LMNATP53THRBALDH1A1 | |
| SCHEMBL17358767 | 0.76 | BRD4 (0.45) | LMNABRD4ALOX5KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |