SCHEMBL8778334

SCHEMBL8778334

Oc1ccccc1-c1cccc(-c2ccccc2)c1O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.70
ALDH1A1 P00352 2/20 0.70
HSD17B10 Q99714 2/20 0.70
BCL2L1 Q07817 1/20 0.70
HDAC4 P56524 2/20 0.54
HDAC2 Q92769 2/20 0.54
HDAC8 Q9BY41 2/20 0.54
HDAC6 Q9UBN7 1/20 0.54
HNF4A P41235 1/20 0.53
BACE1 P56817 3/20 0.52
F7 P08709 1/20 0.46
BRD4 O60885 1/20 0.46
NR1I2 O75469 1/20 0.46
SMARCA2 P51531 1/20 0.46
SMARCA4 P51532 1/20 0.46
PBRM1 Q86U86 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
ALOX5 P09917 1/20 0.45
HSD17B1 P14061 1/20 0.44
HSD17B2 P37059 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Phenylphenol SCHEMBL29058650 0.93 HPGD (0.81) HPGDALDH1A1HSD17B10BCL2L1HDAC4
SCHEMBL2493453 0.91 HPGD (0.70) HPGDALDH1A1HSD17B10BCL2L1HDAC4
SCHEMBL9487300 0.91 HDAC4 (0.62) HPGDALDH1A1HSD17B10BCL2L1HDAC4
SCHEMBL30688232 0.91 HDAC4 (0.62) HPGDALDH1A1HSD17B10BCL2L1HDAC4
SCHEMBL30605196 0.88 HDAC4 (0.65) HPGDALDH1A1HSD17B10BCL2L1HDAC4
SCHEMBL60283 0.88 HDAC4 (0.65) HPGDALDH1A1HSD17B10BCL2L1HDAC4
SCHEMBL1697197 0.88 ALDH1A1 (0.55) HPGDALDH1A1HSD17B10BCL2L1F7
SCHEMBL9767873 0.88 HPGD (0.54) HPGDALDH1A1HSD17B10BCL2L1HDAC4
2-Phenylphenol SCHEMBL6281143 0.86 HPGD (0.77) HPGDALDH1A1HSD17B10BCL2L1HDAC4
SCHEMBL29365218 0.86 ALDH1A1 (0.68) HPGDALDH1A1HSD17B10BCL2L1HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2851359-B1 METHOD FOR PRODUCING 4,4''-DIHYDROXY-M-TERPHENYLS HONSHU CHEMICAL IND (JP) 2017-03-29 EP disclosed
US-9102596-B2 Method of manufacturing 4,4″-dihydroxy-m-terphenyl HONSHU CHEMICAL INDUSTRY CO., LTD. (JP) 2015-08-11 US disclosed
US-20150158800-A1 METHOD OF MANUFACTURING 4,4\"-DIHYDROXY-M-TERPHENYL HONSHU CHEMICAL INDUSTRY CO., LTD. (JP) 2015-06-11 US disclosed
EP-2851359-A1 METHOD FOR PRODUCING 4,4''-DIHYDROXY-M-TERPHENYLS Honshu Chemical Industry Co., Ltd. (JP) 2015-03-25 EP disclosed
EP-0813560-A2 SOLUBLE FLUORINATED POLY-P-PHENYLENES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-12-29 EP disclosed
WO-1996028491-A1 SOLUBLE FLUORINATED POLY-P-PHENYLENES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-09-19 WO disclosed
US-5153300-A Aromatic polyesters with high glass transition temperature, improved solvent resistance GENERAL ELECTRIC COMPANY (US) 1992-10-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150158800-A1 METHOD OF MANUFACTURING 4,4\"-DIHYDROXY-M-TERPHENYL CYP1A1, CYP4B1, CYP1B1 HPGD 607/4885ALDH1A1 237/4885HSD17B10 108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.