Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1508243 | 0.78 | NOTUM (0.44) | MAPK14MAOAMAOB | |
| SCHEMBL29408351 | 0.76 | CES1 (0.90) | CES1AKR1B1MAPK14TDP1L3MBTL1 | |
| SCHEMBL29437756 | 0.76 | CES1 (0.90) | CES1AKR1B1MAPK14TDP1L3MBTL1 | |
| SCHEMBL44496 | 0.76 | CES1 (0.90) | CES1AKR1B1MAPK14TDP1L3MBTL1 | |
| SCHEMBL9642938 | 0.75 | CES1 (0.59) | CES1AKR1B1MAPK14TDP1L3MBTL1 | |
| SCHEMBL11683792 | 0.75 | CES1 (0.59) | CES1AKR1B1MAPK14TDP1L3MBTL1 | |
| SCHEMBL4221971 | 0.75 | CES1 (0.59) | CES1AKR1B1MAPK14TDP1L3MBTL1 | |
| SCHEMBL8076308 | 0.75 | CES1 (0.59) | CES1AKR1B1MAPK14TDP1L3MBTL1 | |
| SCHEMBL4175611 | 0.75 | CES1 (0.59) | CES1AKR1B1MAPK14TDP1L3MBTL1 | |
| SCHEMBL4165982 | 0.75 | CES1 (0.59) | CES1AKR1B1MAPK14TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0814081-A1 | Drug resistance and multidrug resistance modulators | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |