Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11673017 | 0.84 | MAOA (0.61) | CES1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL16559358 | 0.83 | NPC1 (0.47) | CES1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11905992 | 0.83 | MAPK14 (0.65) | CES1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL44496 | 0.80 | CES1 (0.90) | CES1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL29437756 | 0.80 | CES1 (0.90) | CES1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL29408351 | 0.80 | CES1 (0.90) | CES1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7820829 | 0.80 | CES1 (0.61) | CES1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8076308 | 0.79 | CES1 (0.59) | CES1MAPK14AKR1B1TDP1L3MBTL1 | |
| SCHEMBL9642938 | 0.79 | CES1 (0.59) | CES1MAPK14AKR1B1TDP1L3MBTL1 | |
| SCHEMBL4175611 | 0.79 | CES1 (0.59) | CES1MAPK14AKR1B1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105327-A1 | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds | MERCKLE GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
| EP-1881968-A2 | DIBENZOCYCLOHEPTANE COMPOUNDS AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS | MERCKLE GMBH (DE) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006120010-A2 | DIBENZOCYCLOHEPTANE COMPOUNDS AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS | MERCKLE GMBH (DE) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105327-A1 | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds | BDKRB1, IL1R1, IL1A | CES1 156/4885MAPK14 3479/4885MAPK13 3037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.