Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8778968 | 0.84 | MEN1 (0.36) | KMT2AMEN1L3MBTL1DRD2HTR2A | |
| SCHEMBL8778955 | 0.81 | AR (0.33) | AR | |
| SCHEMBL769176 | 0.71 | MEN1 (0.42) | ARKMT2AMEN1L3MBTL1 | |
| SCHEMBL8779128 | 0.71 | F7 (0.46) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL8365778 | 0.71 | MEN1 (0.44) | KMT2AMEN1L3MBTL1HTR2AHTR2C | |
| SCHEMBL31140123 | 0.71 | MEN1 (0.44) | KMT2AMEN1L3MBTL1HTR2AHTR2C | |
| SCHEMBL8779031 | 0.68 | SIGMAR1 (0.40) | L3MBTL1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL8779094 | 0.68 | SIGMAR1 (0.57) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL8779030 | 0.67 | SIGMAR1 (0.39) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL8779154 | 0.65 | PARP1 (0.46) | DRD2HTR2AHTR2CHTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606661-B1 | Octahydrophenanthrene derivatives and their use as NMDA-Antagonists | HOFFMANN LA ROCHE (CH) | 1997-03-12 | — | — | EP | disclosed |
| US-5385947-A | For prevention of nerve damage due to reduction of blood or oxygen supplies | HOFFMANN-LA ROCHE INC. (US) | 1995-01-31 | — | — | US | disclosed |
| EP-0606661-A1 | Octahydrophenanthrene derivatives and their use as NMDA-Antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1994-07-20 | — | — | EP | disclosed |