Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779176 | 1.00 | HPGD (0.38) | HPGDSMN1; SMN2GAACARM1PRMT6 | |
| SCHEMBL8779325 | 0.91 | IKBKB (0.37) | HPGDSMN1; SMN2GAACARM1PRMT6 | |
| SCHEMBL8779136 | 0.91 | IKBKB (0.37) | HPGDSMN1; SMN2GAACARM1PRMT6 | |
| SCHEMBL8779135 | 0.90 | XIAP (0.40) | SMN1; SMN2CARM1PRMT6LMNA | |
| SCHEMBL8779157 | 0.90 | XIAP (0.40) | SMN1; SMN2CARM1PRMT6LMNA | |
| SCHEMBL8779292 | 0.89 | CARM1 (0.35) | SMN1; SMN2CARM1PRMT6AAK1 | |
| SCHEMBL8779231 | 0.89 | CARM1 (0.33) | GAACARM1PRMT6AAK1 | |
| SCHEMBL8779165 | 0.89 | XIAP (0.38) | SMN1; SMN2CARM1PRMT6KMT2ALMNA | |
| SCHEMBL8779264 | 0.88 | AAK1 (0.35) | CARM1PRMT6GRIN3BGRIN1GRIN2C | |
| SCHEMBL8779278 | 0.87 | HTT (0.39) | CARM1PRMT6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |