Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 6/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779325 | 1.00 | IKBKB (0.37) | IKBKBXIAPCARM1PRMT6HSD17B10 | |
| SCHEMBL8779135 | 0.94 | XIAP (0.40) | XIAPCARM1PRMT6SLC15A1ACACB | |
| SCHEMBL8779157 | 0.94 | XIAP (0.40) | XIAPCARM1PRMT6SLC15A1ACACB | |
| SCHEMBL8779165 | 0.93 | XIAP (0.38) | XIAPCARM1PRMT6MAPTSLC15A1 | |
| SCHEMBL8779212 | 0.91 | HPGD (0.38) | IKBKBCARM1PRMT6KDM4EALDH1A1 | |
| SCHEMBL8779176 | 0.91 | HPGD (0.38) | IKBKBCARM1PRMT6KDM4EALDH1A1 | |
| SCHEMBL8779278 | 0.90 | HTT (0.39) | CARM1PRMT6ACACBMAPK1KDM4E | |
| SCHEMBL8779183 | 0.89 | REN (0.35) | IKBKBCARM1PRMT6ACACB | |
| SCHEMBL8779140 | 0.89 | REN (0.35) | IKBKBCARM1PRMT6ACACB | |
| SCHEMBL8779292 | 0.87 | CARM1 (0.35) | CARM1PRMT6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |