Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.77 |
| ▸ | HTT | P42858 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 7/20 | 0.67 |
| ▸ | SRC | P12931 | 7/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.64 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.61 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779364 | 0.88 | SMN1; SMN2 (0.79) | CYP1A2CYP2C19HTTSMN1; SMN2MEN1 | |
| SCHEMBL3612969 | 0.86 | SMN1; SMN2 (0.76) | CYP1A2CYP2C19HTTSMN1; SMN2MEN1 | |
| SCHEMBL9018863 | 0.86 | SMN1; SMN2 (0.72) | CYP1A2CYP2C19HTTSMN1; SMN2MEN1 | |
| SCHEMBL8779363 | 0.85 | HTT (0.73) | CYP1A2CYP2C19HTTSMN1; SMN2MEN1 | |
| SCHEMBL8779378 | 0.83 | ABL1 (0.70) | CYP1A2CYP2C19HTTSMN1; SMN2MEN1 | |
| SCHEMBL14970925 | 0.81 | LMNA (0.67) | CYP1A2CYP2C19HTTSMN1; SMN2MEN1 | |
| SCHEMBL28417113 | 0.77 | GAA (0.63) | CYP1A2CYP2C19HTTMEN1KMT2A | |
| SCHEMBL28972740 | 0.77 | ABL1 (0.67) | CYP1A2CYP2C19HTTSMN1; SMN2MEN1 | |
| SCHEMBL5181389 | 0.75 | SMN1; SMN2 (0.69) | CYP1A2CYP2C19HTTSMN1; SMN2MEN1 | |
| SCHEMBL8779367 | 0.75 | KMT2A (0.64) | CYP1A2CYP2C19HTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | claimed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | claimed |