Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.76 |
| ▸ | HTT | P42858 | 1/20 | 0.76 |
| ▸ | ABL1 | P00519 | 3/20 | 0.70 |
| ▸ | SRC | P12931 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.67 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.67 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.65 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779364 | 0.88 | SMN1; SMN2 (0.79) | SMN1; SMN2CYP1A2CYP2C19HTTABL1 | |
| SCHEMBL8779340 | 0.86 | CYP1A2 (0.77) | SMN1; SMN2CYP1A2CYP2C19HTTABL1 | |
| SCHEMBL8779355 | 0.86 | RAB9A (0.70) | SMN1; SMN2ABL1SRCRAB9AALDH1A1 | |
| SCHEMBL8779366 | 0.85 | ABL1 (0.84) | SMN1; SMN2ABL1SRCRAB9AALDH1A1 | |
| SCHEMBL8779363 | 0.84 | HTT (0.73) | SMN1; SMN2CYP1A2CYP2C19HTTABL1 | |
| SCHEMBL8779385 | 0.84 | MEN1 (0.58) | SMN1; SMN2CYP1A2CYP2C19HTTABL1 | |
| SCHEMBL28451175 | 0.84 | ABL1 (0.67) | SMN1; SMN2CYP1A2CYP2C19ABL1SRC | |
| SCHEMBL9018863 | 0.83 | SMN1; SMN2 (0.72) | SMN1; SMN2CYP1A2CYP2C19HTTABL1 | |
| SCHEMBL8779318 | 0.83 | ABL1 (0.65) | SMN1; SMN2ABL1SRCRAB9AALDH1A1 | |
| SCHEMBL8779378 | 0.82 | ABL1 (0.70) | SMN1; SMN2CYP1A2CYP2C19HTTABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743574-B1 | Migration imaging members | XEROX CORP (US) | 2000-12-27 | — | — | EP | claimed |
| EP-0743573-B1 | Method for obtaining image contrast migration imaging members | XEROX CORP (US) | 2000-09-06 | — | — | EP | claimed |
| EP-0673784-B1 | Recording sheets containing oxazole, isooxazole, oxazolidinone, oxazoline salts, morpholine, thiazole, thiazolidine, thiadiazole, and phenothiazine compounds | XEROX CORP (US) | 1999-10-27 | — | — | EP | claimed |
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | claimed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | claimed |
| US-4810397-A | ALUMINUM COMPOUND, ACID, THIADIAZOLE OR TRIAZOLE | UNION OIL COMPANY OF CALIFORNIA (US) | 1989-03-07 | — | — | US | claimed |
| US-4719001-A | ALUMINUM COMPOUND AND THIADIAZOLE DERIVATIVE | UNION OIL COMPANY OF CALIFORNIA (US) | 1988-01-12 | — | — | US | claimed |
| US-9284287-B1 | Compositions and methods for the suppression of carbonic anhydrase activity | CELLIX BIO PRIVATE LIMITED (IN) | 2016-03-15 | — | — | US | disclosed |
| US-20100029685-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2010-02-04 | — | — | US | disclosed |
| US-20100029685-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2010-02-04 | — | — | US | disclosed |
| US-20100029685-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2010-02-04 | — | — | US | disclosed |
| EP-2079734-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NeuroSearch A/S (DK) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008049864-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2008-05-02 | — | — | WO | disclosed |
| WO-2008049864-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2008-05-02 | — | — | WO | disclosed |
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | disclosed |
| US-5401853-A | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.R.L. (IT) | 1995-03-28 | — | — | US | disclosed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | disclosed |
| US-4810397-A | ALUMINUM COMPOUND, ACID, THIADIAZOLE OR TRIAZOLE | UNION OIL COMPANY OF CALIFORNIA (US) | 1989-03-07 | — | — | US | disclosed |
| US-4719001-A | ALUMINUM COMPOUND AND THIADIAZOLE DERIVATIVE | UNION OIL COMPANY OF CALIFORNIA (US) | 1988-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029685-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA3, CHRNA5, CHRNB3 | SMN1; SMN2 274/4885CYP1A2 940/4885CYP2C19 1472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.