Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GLS | O94925 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5181389 | 0.87 | SMN1; SMN2 (0.69) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL9720512 | 0.84 | RAB9A (0.67) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL8356401 | 0.83 | SMN1; SMN2 (0.61) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL11117150 | 0.82 | SMN1; SMN2 (0.58) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL10878301 | 0.79 | SMN1; SMN2 (0.54) | RAB9ASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL8779354 | 0.78 | RAB9A (0.59) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL11717238 | 0.78 | RAB9A (0.55) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL11561076 | 0.76 | RAB9A (0.54) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL19370459 | 0.76 | SMN1; SMN2 (0.53) | RAB9ASMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL11642903 | 0.76 | SMN1; SMN2 (0.54) | RAB9AMAPTNPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | claimed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | claimed |