Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 12/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779669 | 1.00 | MEN1 (0.57) | MEN1KMT2ARAB9ANPC1GAA | |
| SCHEMBL3327410 | 0.74 | ALDH1A1 (0.60) | MEN1KMT2ARAB9ANPC1GAA | |
| SCHEMBL29539937 | 0.74 | ALDH1A1 (0.60) | MEN1KMT2ARAB9ANPC1GAA | |
| SCHEMBL3327414 | 0.74 | ALDH1A1 (0.60) | MEN1KMT2ARAB9ANPC1GAA | |
| SCHEMBL8779657 | 0.72 | CYP2C9 (0.55) | MEN1KMT2ANPC1GAAALDH1A1 | |
| SCHEMBL8779651 | 0.72 | CYP2C9 (0.55) | MEN1KMT2ANPC1GAAALDH1A1 | |
| SCHEMBL8779760 | 0.71 | ALDH1A1 (0.47) | MEN1KMT2ARAB9AGAAALDH1A1 | |
| SCHEMBL8779758 | 0.71 | ALDH1A1 (0.47) | MEN1KMT2ARAB9AGAAALDH1A1 | |
| SCHEMBL15421801 | 0.71 | PIM1 (0.68) | MEN1KMT2ARAB9ANPC1GAA | |
| SCHEMBL28084957 | 0.71 | MEN1 (0.60) | MEN1KMT2ARAB9ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525197-B1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOGS | SHIONOGI & CO (JP) | 1997-08-27 | — | — | EP | disclosed |
| US-5319100-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| US-5319099-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| EP-0525197-A1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOG | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-02-03 | — | — | EP | disclosed |