Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 15/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 13/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1125003 | 0.83 | TP53 (0.64) | USP2TP53MAPK1RECQLHSD17B10 | |
| SCHEMBL8780428 | 0.78 | ALDH1A1 (0.38) | USP2TP53MAPK1RECQLHSD17B10 | |
| SCHEMBL1125190 | 0.78 | NR1H2 (0.57) | USP2TP53MAPK1RECQLHSD17B10 | |
| SCHEMBL11201153 | 0.76 | NR1H2 (0.53) | USP2TP53MAPK1RECQLHSD17B10 | |
| SCHEMBL11618867 | 0.76 | NR1H2 (0.53) | USP2TP53MAPK1RECQLHSD17B10 | |
| Hydrochloric Acid SCHEMBL11618873 | 0.76 | NR1H2 (0.56) | USP2TP53MAPK1RECQLHSD17B10 | |
| SCHEMBL2650510 | 0.76 | L3MBTL1 (0.36) | HSD17B10GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1124374 | 0.73 | NR1H2 (0.73) | NR1H2NR1H3MAPT | |
| SCHEMBL7069485 | 0.73 | TP53 (0.59) | USP2TP53MAPK1RECQLHSD17B10 | |
| Ethylbenzene SCHEMBL16672933 | 0.71 | ALDH1A1 (0.43) | MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498722-B1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-07-30 | — | — | EP | claimed |
| EP-0498722-B1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-07-30 | — | — | EP | disclosed |