Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118013 | 0.80 | AGTR1 (0.47) | TLR8TSHRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8780493 | 0.80 | TLR8 (0.42) | TLR8TSHRHSD17B10SMOALDH1A1 | |
| SCHEMBL18554028 | 0.77 | TLR8 (0.38) | TLR8ABCG2SMOSLC22A12CYP2A6 | |
| SCHEMBL8675220 | 0.75 | KDM4E (0.44) | TLR8TSHRHSD17B10PDE10AALDH1A1 | |
| SCHEMBL8504620 | 0.75 | BRS3 (0.54) | — | |
| SCHEMBL8780501 | 0.75 | MEN1 (0.42) | TLR8TSHRHSD17B10ABCG2ALDH1A1 | |
| SCHEMBL9723340 | 0.74 | PTPN1 (0.41) | PDE10A | |
| SCHEMBL18270667 | 0.74 | TLR7 (0.51) | TLR8HSD17B10ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8501923 | 0.73 | AGTR1 (0.50) | — | |
| SCHEMBL27668508 | 0.69 | TLR7 (0.47) | TLR8TSHRHSD17B10ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4338378-A | — | — | None | — | — | JP | disclosed |
| EP-0498722-B1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-07-30 | — | — | EP | disclosed |
| US-5478938-A | Antagonists for angiotensin II receptors; hypotensive, cardiotonic agents; cognitive activators | ROUSSEL UCLAF (FR) | 1995-12-26 | — | — | US | disclosed |
| US-5324839-A | Hypotensive agents, gastrointestinal and urogenital disorders | ROUSSEL-UCLAF (FR) | 1994-06-28 | — | — | US | disclosed |
| JP-H04338378-A | NOVEL NITROGENOUS BICYCLIC DERIVATIVE SUBSTITUTED WITH BENZYL GROUP, THEIR PRODUCTION, RESULTED NOVEL INTERMEDIATE, ITS USE AS DRUG AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | ROUSSEL UCLAF | 1992-11-25 | — | — | JP | disclosed |
| EP-0498722-A1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1992-08-12 | — | — | EP | disclosed |