Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.45 |
| ▸ | BRS3 | P32247 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8504620 | 0.89 | BRS3 (0.54) | AGTR1AGTR2BRS3 | |
| SCHEMBL8584304 | 0.83 | AGTR1 (0.49) | AGTR1AGTR2LTB4R2ACHEPLA2G2A | |
| SCHEMBL9723340 | 0.82 | PTPN1 (0.41) | AGTR1AGTR2LTB4R2BRS3 | |
| SCHEMBL8501790 | 0.80 | PLA2G2A (0.52) | AGTR1AGTR2LTB4R2ACHEPLA2G2A | |
| SCHEMBL9118013 | 0.78 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL8504880 | 0.78 | AGTR1 (0.60) | AGTR1AGTR2LTB4R2ACHEPLA2G2A | |
| SCHEMBL8674166 | 0.77 | PLA2G2A (0.44) | AGTR1AGTR2ACHEPLA2G2ABRS3 | |
| SCHEMBL8979743 | 0.77 | AGTR1 (0.52) | AGTR1AGTR2LTB4R2ACHEBDKRB1 | |
| SCHEMBL8501882 | 0.77 | MAPT (0.48) | AGTR1AGTR2LTB4R2ACHEPLA2G2A | |
| SCHEMBL7835618 | 0.76 | BRS3 (0.52) | AGTR1AGTR2LTB4R2BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004979-A | ANGIOTENSIN II INHIBITORS; 4-((CARBOXY)ARYLOXY)-QUINOLINE DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1999-12-21 | — | — | US | disclosed |
| US-5817674-A | ANTIOTENSIN II RECEPTOR ANTAGONISTS | ROUSSEL UCLAF (FR) | 1998-10-06 | — | — | US | disclosed |