Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8413948 | 0.87 | SMN1; SMN2 (0.47) | POLBHTTRXFP1ALDH1A1KDM4E | |
| SCHEMBL2809797 | 0.85 | ALDH1A1 (0.52) | RXFP1ALDH1A1KDM4EHPGDDHODH | |
| SCHEMBL7851755 | 0.82 | ALDH1A1 (0.45) | POLBRXFP1ALDH1A1KDM4EHPGD | |
| SCHEMBL27978854 | 0.80 | ERN1 (0.49) | POLBHTTRXFP1ALDH1A1KDM4E | |
| SCHEMBL20606236 | 0.78 | MAPT (0.47) | ALDH1A1KDM4EDHODHMAPTSMN1; SMN2 | |
| SCHEMBL10647975 | 0.78 | TLR8 (0.52) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL2908831 | 0.77 | ALDH1A1 (0.62) | HTTALDH1A1DHODHMAPTSMN1; SMN2 | |
| SCHEMBL7568434 | 0.77 | TLR8 (0.53) | POLBHTTRXFP1ALDH1A1KDM4E | |
| SCHEMBL296952 | 0.74 | ALDH1A1 (0.63) | POLBALDH1A1KDM4EDHODHMAPT | |
| SCHEMBL29849579 | 0.74 | ALDH1A1 (0.63) | POLBALDH1A1KDM4EDHODHMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498722-B1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-07-30 | — | — | EP | disclosed |
| EP-0498722-A1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1992-08-12 | — | — | EP | disclosed |