Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780485 | 0.85 | POLB (0.49) | ALDH1A1MAPTSMN1; SMN2KDM4ERXFP1 | |
| SCHEMBL20606236 | 0.83 | MAPT (0.47) | ALDH1A1MAPTSMN1; SMN2KDM4ETDP1 | |
| SCHEMBL4264702 | 0.80 | KDM4E (0.47) | ALDH1A1MAPTSMN1; SMN2KDM4ERXFP1 | |
| SCHEMBL296952 | 0.79 | ALDH1A1 (0.63) | ALDH1A1MAPTSMN1; SMN2KDM4EDYRK1A | |
| SCHEMBL29849579 | 0.79 | ALDH1A1 (0.63) | ALDH1A1MAPTSMN1; SMN2KDM4EDYRK1A | |
| SCHEMBL20606741 | 0.79 | KMT2A (0.52) | ALDH1A1MAPTSMN1; SMN2KDM4EGAA | |
| SCHEMBL2908831 | 0.78 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2DYRK1ADHODH | |
| SCHEMBL27999716 | 0.78 | POLB (0.50) | ALDH1A1MAPTSMN1; SMN2KDM4ERXFP1 | |
| SCHEMBL6818967 | 0.78 | GPR3 (0.50) | ALDH1A1SMN1; SMN2KDM4ERXFP1TDP1 | |
| SCHEMBL27775101 | 0.78 | ALDH1A1 (0.57) | ALDH1A1MAPTSMN1; SMN2KDM4EDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040706-B2 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-8609845-B2 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2013-12-17 | — | — | US | disclosed |
| EP-1836201-B2 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH INC (US) | 2013-09-04 | — | — | EP | disclosed |
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2010-09-23 | — | — | US | disclosed |
| EP-1836201-B1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH INC (US) | 2010-08-11 | — | — | EP | disclosed |
| US-20090318409-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2009-12-24 | — | — | US | disclosed |
| US-20090176822-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2009-07-09 | — | — | US | disclosed |
| EP-1836201-A1 | PYRROLIDINE INHIBITORS OF IAP | Genentech, Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20060167066-A1 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2006-07-27 | — | — | US | disclosed |
| WO-2006069063-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | REN, AGTR1, AGTR2 | ALDH1A1 2202/4885MAPT 2380/4885SMN1; SMN2 3903/4885 |
| US-20090176822-A1 | PYRROLIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC2 | ALDH1A1 4197/4885MAPT 2677/4885SMN1; SMN2 2913/4885 |
| US-20060167066-A1 | Pyrrolidine inhibitors of IAP | BIRC5, XIAP, BIRC2 | ALDH1A1 4211/4885MAPT 2689/4885SMN1; SMN2 2937/4885 |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC2 | ALDH1A1 4197/4885MAPT 2677/4885SMN1; SMN2 2913/4885 |
| US-20090318409-A1 | PYRROLIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC2 | ALDH1A1 4197/4885MAPT 2677/4885SMN1; SMN2 2913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.