Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780856 | 0.80 | GRIN1 (0.50) | KCNH2ALDH1A1ADRB2ADRB1ADRB3 | |
| SCHEMBL8780849 | 0.77 | KCNH2 (0.47) | KCNH2ALDH1A1NPC1RAB9AGRIN1 | |
| SCHEMBL8780850 | 0.75 | KCNH2 (0.59) | KCNH2ALDH1A1NPC1RAB9AGRIN1 | |
| SCHEMBL8780876 | 0.74 | NPC1 (0.48) | KCNH2ALDH1A1NPC1RAB9ASLC6A2 | |
| SCHEMBL8780896 | 0.73 | KCNH2 (0.42) | KCNH2ALDH1A1GRIN1GRIN2B | |
| SCHEMBL8780810 | 0.73 | NPC1 (0.47) | KCNH2ALDH1A1NPC1RAB9ASLC6A2 | |
| SCHEMBL8780917 | 0.73 | NPC1 (0.49) | KCNH2ALDH1A1NPC1RAB9ASLC6A2 | |
| SCHEMBL8780925 | 0.72 | KCNH2 (0.65) | KCNH2ALDH1A1NPC1RAB9AGRIN1 | |
| SCHEMBL8780936 | 0.71 | KCNH2 (0.54) | KCNH2ALDH1A1GRIN1GRIN2B | |
| SCHEMBL8780777 | 0.71 | KCNH2 (0.48) | KCNH2ALDH1A1NPC1RAB9AGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |