Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780850 | 0.88 | KCNH2 (0.59) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8780896 | 0.87 | KCNH2 (0.42) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8780810 | 0.86 | NPC1 (0.47) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8780917 | 0.85 | NPC1 (0.49) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8780876 | 0.85 | NPC1 (0.48) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8780750 | 0.85 | TDP1 (0.37) | KCNH2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL8780925 | 0.84 | KCNH2 (0.65) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8780777 | 0.82 | KCNH2 (0.48) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8780727 | 0.82 | L3MBTL1 (0.44) | ALDH1A1LMNA | |
| SCHEMBL8780907 | 0.81 | PKM (0.52) | KCNH2DRD3ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |