Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | EEF2K | O00418 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877550 | 0.90 | SYK (0.43) | SYKROCK2ROCK1CHEK2PAK1 | |
| SCHEMBL878169 | 0.90 | PRKD3 (0.51) | EGFRITKSYKROCK2ROCK1 | |
| SCHEMBL876565 | 0.89 | PRKD3 (0.48) | EGFRITKSYKROCK2ROCK1 | |
| SCHEMBL877065 | 0.89 | EGFR (0.45) | EGFRITKSYKROCK2ROCK1 | |
| SCHEMBL4798787 | 0.86 | ROCK2 (0.46) | EGFRITKSYKROCK2ROCK1 | |
| SCHEMBL877936 | 0.85 | ROCK2 (0.47) | EGFRITKSYKROCK2ROCK1 | |
| SCHEMBL3792568 | 0.84 | ABCG2 (0.57) | EGFRITKSYKROCK2ROCK1 | |
| SCHEMBL877451 | 0.83 | ABCG2 (0.55) | EGFRITKSYKROCK2ABCG2 | |
| SCHEMBL31484237 | 0.83 | ABCG2 (0.55) | EGFRITKSYKROCK2ABCG2 | |
| SCHEMBL31484236 | 0.83 | ABCG2 (0.55) | EGFRITKSYKROCK2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040499-A2 | METABOLIC INHIBITORS | SURFACE LOGIX, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| EP-1865958-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | Surface Logix, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105081-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. (US) | 2006-10-05 | — | — | WO | disclosed |