Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 4/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6268448 | 0.81 | APP (0.51) | MAOAMAOBSYKAPPNOS1 | |
| SCHEMBL2983424 | 0.80 | MAOA (0.51) | MAOAMAOBAPPCA1CA2 | |
| SCHEMBL2463521 | 0.80 | MAPT (0.68) | MAOAMAOBAPPCA1CA2 | |
| SCHEMBL31438448 | 0.80 | HDAC3 (0.47) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL563869 | 0.80 | HDAC3 (0.47) | MAOAMAOBCA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL6742142 | 0.80 | APP (0.50) | MAOAMAOBSYKAPPNOS1 | |
| Hydrochloric Acid SCHEMBL2989034 | 0.79 | MAOA (0.50) | MAOAMAOBAPPCA1CA2 | |
| SCHEMBL11535127 | 0.79 | MAOA (0.51) | MAOAMAOBAPPNOS1CA1 | |
| SCHEMBL2469342 | 0.78 | HIF1A (0.59) | MAOAMAOBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL7516084 | 0.77 | MAPT (0.55) | APPCA1CA2CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |