SCHEMBL563869

SCHEMBL563869

Nc1ccccc1CNc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC2 Q92769 1/20 0.47
NCOR2 Q9Y618 1/20 0.47
MAPT P10636 4/20 0.46
HIF1A Q16665 3/20 0.46
EGFR P00533 1/20 0.45
MEN1 O00255 2/20 0.43
ALDH1A1 P00352 2/20 0.43
KMT2A Q03164 2/20 0.43
KDM4E B2RXH2 1/20 0.43
LMNA P02545 1/20 0.43
CYP1A2 P05177 1/20 0.43
GAA P10253 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
CA12 O43570 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31438448 1.00 HDAC3 (0.47) HDAC3HDAC1HDAC2NCOR2MAPT
SCHEMBL2983424 0.88 MAOA (0.51) HDAC3HDAC1HDAC2NCOR2MAPT
Hydrochloric Acid SCHEMBL2989034 0.86 MAOA (0.50) HDAC3HDAC1HDAC2NCOR2MAPT
SCHEMBL7516084 0.84 MAPT (0.55) MAPTHIF1AEGFRMEN1ALDH1A1
SCHEMBL10055008 0.84 MAPT (0.53) MAPTHIF1AMEN1ALDH1A1KMT2A
SCHEMBL5044239 0.83 MAPT (0.48) HDAC3HDAC1HDAC2MAPTEGFR
Hydrochloric Acid SCHEMBL455092 0.81 MAPT (0.47) HDAC3HDAC1HDAC2MAPTEGFR
SCHEMBL2477034 0.80 ADRA2B (0.45) MAPTHIF1AMEN1ALDH1A1KMT2A
SCHEMBL8782838 0.80 MAOA (0.53) MAPTEGFRMEN1ALDH1A1KMT2A
SCHEMBL7519446 0.80 MAPT (0.50) MAPTHIF1AEGFRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2268713-B1 PROCESS FOR MAKING POLYAMINOPOLYPHENYL METHANES USING A MIXED SOLID ACID CATALYST SYSTEM DOW GLOBAL TECHNOLOGIES LLC (US) 2018-02-21 EP claimed
EP-2019092-B1 PROCESS FOR PRODUCING POLYAMINE MITSUI CHEMICALS INC (JP) 2013-07-03 EP claimed
EP-2019092-A1 PROCESS FOR PRODUCING POLYAMINE Mitsui Chemicals Polyurethanes, Inc. (JP) 2009-01-28 EP claimed
WO-2025073928-A1 PROCESS FOR PREPARING MDA BASF SE (DE) 2025-04-10 WO disclosed
CN-110088078-B Process for producing di-and polyamines of the diphenylmethane series 科思创德国股份有限公司 2022-09-09 CN disclosed
CN-110072840-B Method for producing di-and polyamines of the diphenylmethane series at different production capacities 科思创德国股份有限公司 2022-09-09 CN disclosed
CN-110291063-B Method for producing diamines and polyamines of the diphenylmethane series at different production capacities 科思创德国股份有限公司 2022-07-05 CN disclosed
EP-3160934-B1 METHOD FOR PRODUCING DI- AND POLYAMINES OF THE DIPHENYLMETHANE SERIES COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2022-01-26 EP disclosed
EP-3160935-B1 METHOD FOR PRODUCING DI- AND POLYAMINES OF THE DIPHENYLMETHANE SERIES COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2021-11-17 EP disclosed
EP-3160936-B1 METHOD FOR PRODUCING DI- AND POLYAMINES OF THE DIPHENYLMETHANE SERIES COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2021-10-13 EP disclosed
EP-3558927-B1 PROCESS FOR THE PREPARATION OF DI- AND POLYAMINES OF THE DIPHENYLMETHANE SERIES COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2021-01-20 EP disclosed
EP-0158953-A2 Triamines, a process for their preparation and their use as cross-linking agents or hardeners for plastic materials or precursers having epoxy or isocyanate-groups BAYER AG (DE) 1985-10-23 EP disclosed
EP-0158952-A2 Triamines, a process for their preparation and their use as cross-linking agents or hardeners for plastic materials or precursors having epoxy- or isocyanate-groups BAYER AG (DE) 1985-10-23 EP disclosed
US-4172948-A REARRANGEMENT IN PRESENCE OF HYDROGEN CHLORIDE CATALYST ATLANTIC RICHFIELD COMPANY (US) 1979-10-30 US disclosed
US-4147724-A Process for the preparation of polyamines BAYER AKTIENGESELLSCHAFT (DE) 1979-04-03 US disclosed
US-4146727-A ACID CATALYSTS ATLANTIC RICHFIELD COMPANY (US) 1979-03-27 US disclosed
US-4093658-A CONDENSING AN AROMATIC AMINE WITH FORMALDEHYDE BAYER AKTIENGESELLSCHAFT (DT) 1978-06-06 US disclosed
US-4087459-A Process for the preparation of polyamines BAYER AKTIENGESELLSCHAFT (DT) 1978-05-02 US disclosed
US-4039581-A Process for the preparation of di(amino phenyl)methanes THE UPJOHN COMPANY (US) 1977-08-02 US disclosed
US-3931215-A OPTICAL BRIGHTENERS HOECHST AKTIENGESELLSCHAFT (DT) 1976-01-06 US disclosed