Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 7/20 | 0.36 |
| ▸ | DRD3 | P35462 | 6/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783606 | 0.85 | DRD2 (0.38) | GRIN2BGRIN1DRD2DRD3DRD4 | |
| SCHEMBL8788400 | 0.84 | DRD3 (0.47) | DRD2DRD3DRD4SIGMAR1ADRA1A | |
| SCHEMBL8783017 | 0.76 | GRIN2B (0.58) | GRIN2BGRIN1DRD2DRD3DRD4 | |
| SCHEMBL8784186 | 0.69 | DRD3 (0.48) | DRD2DRD3DRD4SIGMAR1ADRA1A | |
| SCHEMBL30667124 | 0.68 | HTR2A (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL8783410 | 0.67 | DRD2 (0.38) | GRIN2BGRIN1DRD2DRD3DRD4 | |
| SCHEMBL8782868 | 0.65 | DRD2 (0.43) | DRD2DRD3DRD4 | |
| SCHEMBL8783307 | 0.64 | DRD2 (0.58) | DRD2DRD3DRD4 | |
| Bromide SCHEMBL9449301 | 0.63 | DRD2 (0.56) | DRD2DRD3DRD4 | |
| SCHEMBL8783223 | 0.61 | GRIN2B (0.50) | GRIN2BGRIN1DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395244-B1 | Pyridine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| US-5194439-A | 5-HT Agonists or Antagonists, Nervous System Disorders, Hypotensive Agents | JOHN WYETH & BROTHER LIMITED (GB) | 1993-03-16 | — | — | US | disclosed |
| EP-0395244-A1 | Pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1990-10-31 | — | — | EP | disclosed |