Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | AR | P10275 | 6/20 | 0.57 |
| ▸ | CCNC | P24863 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | GABRP | O00591 | 2/20 | 0.48 |
| ▸ | GABRD | O14764 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.48 |
| ▸ | GABRE | P78334 | 2/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.48 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782817 | 0.82 | LCK (0.62) | LCKEGFRSRCARCCNC | |
| SCHEMBL8782557 | 0.82 | LCK (0.62) | LCKEGFRSRCARCCNC | |
| SCHEMBL8782616 | 0.81 | LCK (0.50) | LCKEGFRSRCARCCNC | |
| SCHEMBL8782447 | 0.81 | NPC1 (0.52) | LCKARABCB1ESR1ESR2 | |
| SCHEMBL8782297 | 0.81 | AR (0.44) | LCKEGFRSRCARGABRP | |
| SCHEMBL8783200 | 0.78 | LCK (0.50) | LCKEGFRSRCARCCNC | |
| SCHEMBL1560703 | 0.75 | ESR1 (0.78) | LCKEGFRSRCARCCNC | |
| SCHEMBL3859265 | 0.75 | PTPRS (0.78) | LCKEGFRARCCNCCDK8 | |
| SCHEMBL925553 | 0.73 | EGFR (0.82) | LCKEGFRSRCGABRPGABRD | |
| SCHEMBL8782455 | 0.72 | AR (0.39) | LCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556720-B1 | 5-Aminoflavone derivatives | KYOWA HAKKO KOGYO KK (JP) | 1997-09-17 | — | — | EP | disclosed |
| US-5539112-A | 5-aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-07-23 | — | — | US | disclosed |
| EP-0556720-A1 | 5-Aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |