Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 14/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782871 | 1.00 | ALOX5 (0.40) | ALOX5EPHX2ALDH1A1MAPTKLKB1 | |
| SCHEMBL8783077 | 0.83 | ALOX5 (0.56) | ALOX5ALDH1A1MAPTKLKB1CYP1A2 | |
| SCHEMBL8783087 | 0.83 | ALOX5 (0.56) | ALOX5ALDH1A1MAPTKLKB1CYP1A2 | |
| SCHEMBL8783317 | 0.83 | ALOX5 (0.56) | ALOX5ALDH1A1MAPTKLKB1CYP1A2 | |
| SCHEMBL8782867 | 0.77 | ALOX5 (0.45) | ALOX5EPHX2ALDH1A1MAPTKLKB1 | |
| SCHEMBL8782860 | 0.77 | ALOX5 (0.45) | ALOX5EPHX2ALDH1A1MAPTKLKB1 | |
| SCHEMBL8782995 | 0.77 | ALOX5 (0.45) | ALOX5EPHX2ALDH1A1MAPTKLKB1 | |
| SCHEMBL8783114 | 0.73 | ALOX5 (0.55) | ALOX5EPHX2ALDH1A1MAPTKLKB1 | |
| SCHEMBL9207904 | 0.73 | ALOX5 (0.69) | ALOX5ALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL8942609 | 0.69 | ALOX5 (0.52) | ALOX5ALDH1A1MAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | claimed |
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |