Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 14/20 | 0.52 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942778 | 0.89 | ALDH1A1 (0.42) | ALOX5CARM1PRMT6MAPTALDH1A1 | |
| SCHEMBL8942588 | 0.89 | ALDH1A1 (0.42) | ALOX5CARM1PRMT6MAPTALDH1A1 | |
| SCHEMBL8783087 | 0.85 | ALOX5 (0.56) | ALOX5CARM1PRMT6MAPTALDH1A1 | |
| SCHEMBL8783317 | 0.85 | ALOX5 (0.56) | ALOX5CARM1PRMT6MAPTALDH1A1 | |
| SCHEMBL8783077 | 0.85 | ALOX5 (0.56) | ALOX5CARM1PRMT6MAPTALDH1A1 | |
| SCHEMBL8942397 | 0.83 | ALOX5 (0.52) | ALOX5CARM1PRMT6 | |
| SCHEMBL8942621 | 0.83 | ALOX5 (0.52) | ALOX5CARM1PRMT6 | |
| SCHEMBL8942835 | 0.83 | ALOX5 (0.52) | ALOX5CARM1PRMT6 | |
| SCHEMBL8942749 | 0.81 | ALOX5 (0.48) | ALOX5CARM1PRMT6MEN1KMT2A | |
| SCHEMBL8942311 | 0.80 | ALOX5 (0.49) | ALOX5MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |