Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876436 | 0.90 | SLC2A1 (0.35) | TLR9TLR8TLR7PDK2F10 | |
| SCHEMBL876498 | 0.86 | SLC2A1 (0.38) | PDK2F10POLBCNR2JAK2 | |
| SCHEMBL875679 | 0.84 | F10 (0.34) | TLR9TLR8TLR7PDK2F10 | |
| SCHEMBL875502 | 0.79 | ALDH1A1 (0.34) | PDK2F10POLB | |
| SCHEMBL876159 | 0.78 | NPC1 (0.35) | PDK2F10POLBKDM4CGPR55 | |
| SCHEMBL878327 | 0.77 | TLR9 (0.36) | TLR9TLR8TLR7PDK2F10 | |
| SCHEMBL878362 | 0.77 | TLR9 (0.36) | TLR9TLR8TLR7F10POLB | |
| SCHEMBL785591 | 0.76 | F10 (0.44) | TLR9TLR8TLR7PDK2F10 | |
| SCHEMBL784885 | 0.75 | TLR9 (0.42) | TLR9TLR8TLR7F10POLB | |
| SCHEMBL784539 | 0.74 | TLR9 (0.43) | TLR9TLR8TLR7PDK2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |