Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.58 |
| ▸ | GABRD | O14764 | 3/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.58 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.58 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.58 |
| ▸ | GABRE | P78334 | 3/20 | 0.58 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.58 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.58 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.58 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783611 | 0.94 | HTR1D (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8784148 | 0.84 | GABRP (0.63) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8784268 | 0.83 | OPRM1 (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8783749 | 0.82 | GABRP (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8784342 | 0.81 | HTR1A (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8784982 | 0.80 | OPRM1 (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8784524 | 0.80 | KDM4E (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8783956 | 0.80 | KDM4E (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8572226 | 0.79 | KDM4E (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8574883 | 0.79 | KDM4E (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497512-B1 | Imidazole, triazole and tetrazole derivatives | MERCK SHARP & DOHME (GB) | 1997-09-24 | — | — | EP | claimed |
| EP-0778275-A1 | Process for the preparation of imidazole, triazole and tetrazole derivatives and their use as selective 5-HT-1 receptor agonists | MERCK SHARP & DOHME LTD. (GB) | 1997-06-11 | — | — | EP | claimed |
| EP-0497512-A2 | Imidazole, triazole and tetrazole derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-08-05 | — | — | EP | claimed |
| EP-0497512-B1 | Imidazole, triazole and tetrazole derivatives | MERCK SHARP & DOHME (GB) | 1997-09-24 | — | — | EP | disclosed |
| EP-0778275-A1 | Process for the preparation of imidazole, triazole and tetrazole derivatives and their use as selective 5-HT-1 receptor agonists | MERCK SHARP & DOHME LTD. (GB) | 1997-06-11 | — | — | EP | disclosed |
| US-5602163-A | SELECTIVE AGONISTS OF 5-HYDROXYTRYPTAMINE RECEPTORS; USEFUL IN TREATMENT OF MIGRAINE HEADACHES | MERCK, SHARP & DOHME LTD. (GB) | 1997-02-11 | — | — | US | disclosed |
| US-5602162-A | TREATMENT AND/OR PREVENTION OF MIGRAINE | MERCK, SHARP & DOHME LTD. (GB) | 1997-02-11 | — | — | US | disclosed |
| US-5451588-A | Treatment of migraines | MERCK SHARP & DOHME LTD. (GB) | 1995-09-19 | — | — | US | disclosed |
| US-5298520-A | Triazole containing indole derivatives | MERCK SHARP & DOHME LIMITED (GB) | 1994-03-29 | — | — | US | disclosed |
| EP-0497512-A2 | Imidazole, triazole and tetrazole derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-08-05 | — | — | EP | disclosed |