SCHEMBL8784205

SCHEMBL8784205

C#CCN(c1ccc(C(=O)Oc2c(F)c(F)c(F)c(F)c2F)c(F)c1)C1CCc2cc3nc(C)n(COC(=O)C(C)(C)C)c(=O)c3cc21

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 2/20 0.32
ACHE P22303 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8783914 0.90 EIF4EBP1 (0.30)
SCHEMBL8784818 0.90 ACHE (0.31) ACHE
SCHEMBL8783750 0.89 NAMPT (0.32) NAMPT
SCHEMBL9257924 0.83
SCHEMBL9257932 0.83
SCHEMBL8783501 0.83 KMT2A (0.30)
SCHEMBL8485192 0.82
SCHEMBL8784371 0.81 EIF4EBP1 (0.31)
SCHEMBL9202098 0.81 KMT2A (0.35)
SCHEMBL9203133 0.79 KMT2A (0.35) ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0758328-A1 ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING BTG INTERNATIONAL LIMITED (GB) 1997-02-19 EP disclosed
WO-1995030673-A1 ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING BRITISH TECHNOLOGY GROUP LIMITED (GB) 1995-11-16 WO disclosed