Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201272 | 0.89 | CYP3A4 (0.33) | PDE10AKDM4EMEN1POLBKMT2A | |
| SCHEMBL8784802 | 0.86 | P2RX3 (0.36) | EIF4EBP1AGTR1AGTR2KDM4EMEN1 | |
| SCHEMBL8784811 | 0.86 | P2RX3 (0.36) | EIF4EBP1AGTR1AGTR2KDM4EMEN1 | |
| SCHEMBL8783914 | 0.84 | EIF4EBP1 (0.30) | EIF4EBP1 | |
| SCHEMBL9200498 | 0.82 | EIF4EBP1 (0.33) | EIF4EBP1PDE10AKDM4EMEN1POLB | |
| SCHEMBL8783752 | 0.81 | PDE7A (0.34) | EIF4EBP1KDM4EMEN1POLBKMT2A | |
| SCHEMBL8783754 | 0.81 | PDE7A (0.34) | EIF4EBP1KDM4EMEN1POLBKMT2A | |
| SCHEMBL8784252 | 0.81 | EIF4EBP1 (0.34) | EIF4EBP1PDE10AKDM4EMEN1POLB | |
| SCHEMBL8784205 | 0.81 | NAMPT (0.32) | — | |
| SCHEMBL9200500 | 0.81 | EIF4EBP1 (0.34) | EIF4EBP1AGTR1AGTR2PDE10AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758328-A1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BTG INTERNATIONAL LIMITED (GB) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030673-A1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |