Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7522334 | 0.91 | S1PR5 (0.48) | S1PR5S1PR4S1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL7407489 | 0.83 | S1PR5 (0.42) | S1PR5S1PR4S1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL7398353 | 0.77 | GAA (0.45) | S1PR5S1PR4S1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL22675343 | 0.75 | SMN1; SMN2 (0.62) | S1PR5S1PR4S1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL22677330 | 0.75 | SMN1; SMN2 (0.62) | S1PR5S1PR4S1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL13102175 | 0.75 | SMN1; SMN2 (0.62) | S1PR5S1PR4S1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL934458 | 0.75 | SMN1; SMN2 (0.57) | S1PR5S1PR4S1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL13740434 | 0.75 | SMN1; SMN2 (0.57) | S1PR5S1PR4S1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL13739335 | 0.75 | SMN1; SMN2 (0.57) | S1PR5S1PR4S1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL2556051 | 0.74 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1KDM4EGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1301264-A | Pyrrolidine-3-carboxylic acid derivatives and their use as endothelin antagonists | ABBOTT LAB (US) | 2001-06-27 | — | — | CN | disclosed |
| EP-0776324-A1 | ENDOTHELIN ANTAGONISTS | Abbott Laboratories (US) | 1997-06-04 | — | — | EP | disclosed |