Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4248696 | 0.90 | TOP2A (0.39) | TOP2ATOP2BADRB2ALDH1A1POLB | |
| SCHEMBL2825321 | 0.84 | KCNH2 (0.45) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL8785240 | 0.82 | TOP2A (0.54) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL8927420 | 0.82 | ADRB2 (0.51) | TOP2ATOP2BADRB2ALDH1A1KCNH2 | |
| SCHEMBL8785244 | 0.78 | TOP2A (0.39) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL13520173 | 0.76 | TOP2A (0.41) | TOP2ATOP2BADRB2ALDH1A1POLB | |
| SCHEMBL4248699 | 0.76 | TOP2A (0.33) | TOP2ATOP2B | |
| SCHEMBL2601633 | 0.75 | KCNH2 (0.44) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL13945289 | 0.74 | ADRB2 (0.43) | TOP2ATOP2BADRB2ALDH1A1POLB | |
| SCHEMBL2825319 | 0.73 | KCNH2 (0.46) | TOP2ATOP2BADRB2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569563-B2 | Substituted quinolones II | AICURIS GMBH & CO. HK (DE) | 2009-08-04 | — | — | US | disclosed |
| US-20080261964-A1 | Substituted quinolones II | AICURIS GMBH & CO. KG (DE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261964-A1 | Substituted quinolones II | TOP2A, TPMT, TOP2B | TOP2A 1/4885TOP2B 3/4885ADRB2 2234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.