Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KLK7 | P49862 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15850701 | 0.84 | RIPK1 (0.61) | RIPK1RORCABCB1GPR119MEN1 | |
| SCHEMBL10061592 | 0.84 | RIPK1 (0.61) | RIPK1RORCABCB1GPR119MEN1 | |
| SCHEMBL248353 | 0.84 | RIPK1 (0.61) | RIPK1RORCABCB1GPR119MEN1 | |
| SCHEMBL29695962 | 0.81 | MDM2 (0.42) | RIPK1RORCABCB1GPR119MEN1 | |
| SCHEMBL14199221 | 0.81 | ELANE (0.44) | RIPK1RORCABCB1GPR119KLK7 | |
| SCHEMBL9924398 | 0.81 | ELANE (0.44) | RIPK1RORCABCB1GPR119KLK7 | |
| SCHEMBL14050230 | 0.78 | ELANE (0.44) | RIPK1RORCABCB1GPR119KLK7 | |
| SCHEMBL16237822 | 0.78 | ELANE (0.44) | RIPK1RORCABCB1GPR119KLK7 | |
| SCHEMBL5963534 | 0.78 | ELANE (0.44) | RIPK1RORCABCB1GPR119KLK7 | |
| SCHEMBL8952612 | 0.76 | ABCB1 (0.47) | RIPK1RORCABCB1GPR119KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0756590-A1 | SYNTHESIS OF PROTOTYPES FOR RENIN INHIBITORS | Novartis AG (CH) | 1997-02-05 | — | — | EP | disclosed |
| WO-1995029150-A1 | SYNTHESIS OF PROTOTYPES FOR RENIN INHIBITORS | CIBA-GEIGY AG (CH) | 1995-11-02 | — | — | WO | disclosed |