Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | HTR2C | P28335 | 6/20 | 0.49 |
| ▸ | HRH1 | P35367 | 4/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.49 |
| ▸ | DRD1 | P21728 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11541659 | 0.85 | LMNA (0.42) | HTR2AHTR2CHRH1ADRA2ADRD2 | |
| SCHEMBL11615850 | 0.82 | HTR2A (0.46) | HTR2AHTR2CHRH1ADRA2ADRD2 | |
| SCHEMBL9434823 | 0.81 | HTR2A (0.46) | HTR2AHTR2CHRH1ADRA2ADRD2 | |
| SCHEMBL9433490 | 0.79 | HTR2A (0.44) | HTR2AHTR2CHRH1ADRA2ADRD2 | |
| SCHEMBL11098945 | 0.78 | HTR2A (0.43) | HTR2AHTR2CHRH1ADRA2ADRD2 | |
| SCHEMBL9433483 | 0.76 | HRH2 (0.42) | HTR2AHTR2CHRH1ADRA2ADRD2 | |
| SCHEMBL11409655 | 0.75 | KMT2A (0.56) | HTR2AHTR2CHRH1ADRA2ADRD2 | |
| SCHEMBL31098207 | 0.74 | HTR2A (0.47) | HTR2AHTR2CHRH1ADRA2ADRD2 | |
| SCHEMBL5214553 | 0.73 | PTPN1 (0.40) | MEN1LMNAMAPTKMT2AMAPK1 | |
| SCHEMBL6045366 | 0.72 | ALOX5 (0.65) | HTR2BLMNAMAPTHTR7MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534667-B1 | Tricyclic heterocycles as PGE2 antagonists | ZENECA LTD (GB) | 1997-02-05 | — | — | EP | disclosed |
| EP-0480641-B1 | Tricyclic heterocycles | ZENECA LTD (GB) | 1995-04-05 | — | — | EP | disclosed |
| US-5324722-A | Analgesics | G. D. SEARLE & CO. (US) | 1994-06-28 | — | — | US | disclosed |
| US-5317101-A | Antihyperalgesics | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-05-31 | — | — | US | disclosed |
| WO-1993013082-A1 | SUBSTITUTED DIBENZOXAZEPINES OR DIBENZOTHIAZEPINES AND THEIR USE AS PROSTAGLANDIN E2 ANTAGONISTS | G.D. SEARLE & CO. (US) | 1993-07-08 | — | — | WO | disclosed |
| EP-0534667-A1 | Tricyclic heterocycles as PGE2 antagonists | ZENECA LIMITED (GB) | 1993-03-31 | — | — | EP | disclosed |
| US-5189033-A | Analgesics, antiiflammatory agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| EP-0480641-A1 | Tricyclic heterocycles | ZENECA LIMITED (GB) | 1992-04-15 | — | — | EP | disclosed |