Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 5/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.41 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.41 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8386400 | 0.78 | ACHE (0.47) | PIM1PIM2MAPK14 | |
| SCHEMBL413402 | 0.75 | KCNN3 (0.47) | KCNN3KDM5AKDM4CKDM5BCCNT1 | |
| SCHEMBL12132003 | 0.71 | KDM4E (0.44) | PIM1PIM3 | |
| SCHEMBL12960047 | 0.71 | KDM4E (0.46) | CCNT1ROCK2 | |
| SCHEMBL22102122 | 0.70 | KDM5A (0.49) | KCNN3KDM5AKDM4CKDM5BCCNT1 | |
| SCHEMBL22102194 | 0.70 | KDM5A (0.49) | KCNN3KDM5AKDM4CKDM5BCCNT1 | |
| SCHEMBL18525587 | 0.70 | KDM5A (0.49) | KCNN3KDM5AKDM4CKDM5BCCNT1 | |
| SCHEMBL4776208 | 0.69 | KDM5A (0.47) | KCNN3KDM5AKDM4CKDM5BCCNT1 | |
| SCHEMBL28658094 | 0.68 | KDM5A (0.47) | KCNN3KDM5AKDM4CKDM5BCCNT1 | |
| SCHEMBL28658271 | 0.68 | KDM5A (0.50) | KCNN3KDM5AKDM4CKDM5BCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |