Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.49 |
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8788587 | 0.86 | KCNH2 (0.48) | DRD2HTR1AHTR2AKCNH2HTR2C | |
| SCHEMBL1545073 | 0.84 | HTR1A (0.68) | DRD2HTR1AHTR2AKCNH2HTR2C | |
| SCHEMBL8787916 | 0.84 | HTR1A (0.51) | DRD2HTR1AHTR2AKCNH2HTR2C | |
| SCHEMBL8787873 | 0.83 | DRD2 (0.63) | DRD2HTR1AHTR2AKCNH2HTR2C | |
| SCHEMBL3652217 | 0.82 | HTR1A (0.49) | DRD2HTR1AHTR2AKCNH2HTR2C | |
| SCHEMBL8787897 | 0.82 | ACHE (0.48) | DRD2HTR1AHTR2AKCNH2HTR2C | |
| SCHEMBL8788176 | 0.81 | ACHE (0.47) | DRD2HTR1AHTR2AKCNH2HTR2C | |
| Hydrochloric Acid SCHEMBL8788247 | 0.81 | ACHE (0.47) | DRD2HTR1AHTR2AKCNH2HTR2C | |
| Fumaric Acid SCHEMBL8787400 | 0.81 | HTR2A (0.48) | DRD2HTR1AHTR2AKCNH2HTR2C | |
| Fumaric Acid SCHEMBL8871667 | 0.81 | DRD2 (0.55) | DRD2HTR1AHTR2AKCNH2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730452-A4 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST ROUSSEL PHARMA (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0730452-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST MARION ROUSSEL, Inc. (US) | 1996-09-11 | — | — | EP | disclosed |