Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10393870 | 0.92 | ALDH1A1 (0.59) | ALDH1A1HPGDSIGMAR1KDM4EMEN1 | |
| SCHEMBL9367537 | 0.88 | ALDH1A1 (0.58) | ALDH1A1HPGDSIGMAR1KDM4EMEN1 | |
| SCHEMBL8948117 | 0.86 | ALDH1A1 (0.62) | ALDH1A1HPGDSIGMAR1KDM4EMEN1 | |
| SCHEMBL14741026 | 0.85 | ALDH1A1 (0.60) | ALDH1A1HPGDSIGMAR1KDM4EMEN1 | |
| SCHEMBL9684618 | 0.84 | ALDH1A1 (0.63) | ALDH1A1HPGDSIGMAR1KDM4EMEN1 | |
| SCHEMBL8541265 | 0.84 | ALDH1A1 (0.59) | ALDH1A1HPGDSIGMAR1KDM4EMEN1 | |
| SCHEMBL23123120 | 0.83 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL10392904 | 0.82 | ALDH1A1 (0.63) | ALDH1A1HPGDSIGMAR1KDM4EMEN1 | |
| SCHEMBL23123168 | 0.82 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL9464085 | 0.80 | ALDH1A1 (0.56) | ALDH1A1HPGDSIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0478446-B1 | Heterocyclic alkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-11-19 | — | — | EP | disclosed |
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |
| US-5296477-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | disclosed |
| US-5196434-A | Antidepressants, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1993-03-23 | — | — | US | disclosed |
| EP-0478446-A1 | Heterocyclic alkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-04-01 | — | — | EP | disclosed |
| US-4778792-A | Use of 7-acyl benzoxazinones and their derivatives in treating atheromatous disorders | LABORATORIES NEGMA (FR) | 1988-10-18 | — | — | US | disclosed |