Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 5/20 | 0.31 |
| ▸ | RAB9A | P51151 | 5/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.31 |
| ▸ | RELA | Q04206 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8787340 | 1.00 | MAPT (0.33) | MAPTKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL8788471 | 0.92 | ALDH1A1 (0.34) | MAPTKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL8788475 | 0.92 | ALDH1A1 (0.34) | MAPTKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL8786989 | 0.91 | LMNA (0.32) | MAPTKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL8787717 | 0.89 | KMT2A (0.36) | MAPTKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL8787014 | 0.87 | KMT2A (0.34) | MAPTKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL8787018 | 0.87 | KMT2A (0.34) | MAPTKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL8788608 | 0.86 | APP (0.32) | MAPTKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL8788616 | 0.86 | APP (0.32) | MAPTKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL8787363 | 0.85 | SMN1; SMN2 (0.31) | MAPTKMT2AALDH1A1MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681580-B1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5270331-A | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides | PFIZER, INC. (US) | 1993-12-14 | — | — | US | disclosed |