Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8788608 | 1.00 | APP (0.32) | APPHDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL8786989 | 0.91 | LMNA (0.32) | MAPTMEN1KMT2AALDH1A1EGFR | |
| SCHEMBL8787452 | 0.90 | SCN5A (0.33) | HCAR2 | |
| SCHEMBL8787449 | 0.90 | SCN5A (0.33) | HCAR2 | |
| SCHEMBL8787340 | 0.86 | MAPT (0.33) | MAPTMEN1KMT2AALDH1A1EGFR | |
| SCHEMBL8787335 | 0.86 | MAPT (0.33) | MAPTMEN1KMT2AALDH1A1EGFR | |
| SCHEMBL8787731 | 0.86 | HDAC1 (0.34) | HDAC1HDAC11HDAC8HDAC6MAPT | |
| SCHEMBL8788471 | 0.85 | ALDH1A1 (0.34) | MAPTMEN1KMT2AALDH1A1EGFR | |
| SCHEMBL8788475 | 0.85 | ALDH1A1 (0.34) | MAPTMEN1KMT2AALDH1A1EGFR | |
| SCHEMBL8787746 | 0.82 | KMT2A (0.36) | MAPTMEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681580-B1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5270331-A | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides | PFIZER, INC. (US) | 1993-12-14 | — | — | US | disclosed |