Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | USP8 | P40818 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3734647 | 0.73 | ALDH1A1 (0.43) | PARP1ALDH1A1 | |
| SCHEMBL29656653 | 0.73 | ALDH1A1 (0.43) | PARP1ALDH1A1 | |
| SCHEMBL27995333 | 0.71 | CYP11B2 (0.32) | — | |
| SCHEMBL27900871 | 0.70 | PNMT (0.36) | PARP1KDM4EALDH1A1NOTUM | |
| SCHEMBL11116210 | 0.69 | PTPN1 (0.44) | PARP1KDM4EALDH1A1MCL1 | |
| SCHEMBL3259928 | 0.68 | ESR2 (0.47) | CA1CA2USP8USP7KDM4E | |
| SCHEMBL13920714 | 0.67 | PDE3B (0.35) | CA1CA2KDM4EALDH1A1 | |
| SCHEMBL29533046 | 0.67 | PTPN1 (0.44) | PARP1KDM4EALDH1A1 | |
| SCHEMBL21733906 | 0.67 | PTPN1 (0.44) | PARP1KDM4EALDH1A1 | |
| SCHEMBL2423501 | 0.67 | TSHR (0.46) | CA1CA2KDM4EALDH1A1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0499231-B1 | 9-Aminotetrahydroacridines and related compounds, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-05-21 | — | — | EP | disclosed |
| US-5502203-A | FOR ACRIDINE COMPOUNDS USED IN TREATMENT OF ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-03-26 | — | — | US | disclosed |
| US-5382594-A | Cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-01-17 | — | — | US | disclosed |
| US-5210087-A | Cognition Activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-05-11 | — | — | US | disclosed |
| EP-0499231-A1 | 9-Aminotetrahydroacridines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-08-19 | — | — | EP | disclosed |