Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2B | Q02880 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | TP53 | P04637 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | RECQL | P46063 | 3/20 | 0.58 |
| ▸ | NSD2 | O96028 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | TOP2A | P11388 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | MTOR | P42345 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8788420 | 0.92 | BLM (0.61) | TOP2BBLMSMN1; SMN2TP53MEN1 | |
| Mitoxantrone SCHEMBL20597027 | 0.88 | BLM (0.65) | TOP2BBLMSMN1; SMN2TP53MEN1 | |
| SCHEMBL8788424 | 0.86 | ECE1 (0.63) | TOP2BBLMSMN1; SMN2TP53MEN1 | |
| SCHEMBL9193858 | 0.86 | TOP2B (0.73) | TOP2BBLMSMN1; SMN2TP53MEN1 | |
| SCHEMBL8789454 | 0.85 | ECE1 (0.58) | TOP2BBLMSMN1; SMN2TP53MEN1 | |
| SCHEMBL8791572 | 0.83 | ECE1 (0.51) | TOP2BBLMSMN1; SMN2TP53MEN1 | |
| Ametantrone SCHEMBL3344151 | 0.83 | TOP2B (1.00) | TOP2BBLMSMN1; SMN2TP53MEN1 | |
| Ametantrone SCHEMBL29723071 | 0.83 | TOP2B (1.00) | TOP2BBLMSMN1; SMN2TP53MEN1 | |
| SCHEMBL8788938 | 0.82 | ECE1 (0.57) | TOP2BBLMSMN1; SMN2TP53MEN1 | |
| SCHEMBL8789366 | 0.82 | ECE1 (0.52) | TOP2BBLMSMN1; SMN2TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503537-B1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | UNIV VERMONT (US) | 1997-05-14 | — | — | EP | claimed |
| EP-0575526-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1993-12-29 | — | — | EP | claimed |
| WO-1992015300-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO[g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1992-09-17 | — | — | WO | claimed |
| EP-0503537-A1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | THE UNIVERSITY OF VERMONT (US) | 1992-09-16 | — | — | EP | claimed |
| EP-0503537-B1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | UNIV VERMONT (US) | 1997-05-14 | — | — | EP | disclosed |
| EP-0575526-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1993-12-29 | — | — | EP | disclosed |
| WO-1992015300-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO[g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1992-09-17 | — | — | WO | disclosed |
| EP-0503537-A1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | THE UNIVERSITY OF VERMONT (US) | 1992-09-16 | — | — | EP | disclosed |