Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.52 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 3/20 | 0.43 |
| ▸ | CDK8 | P49336 | 3/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15152227 | 0.84 | CDC7 (0.56) | CDC7CYP1A2GRM4TRPM5SYK | |
| SCHEMBL30279147 | 0.78 | CDC7 (0.55) | CDC7CYP1A2GRM4TRPM5SYK | |
| SCHEMBL8311439 | 0.78 | CDC7 (0.55) | CDC7CYP1A2GRM4TRPM5SYK | |
| SCHEMBL3274399 | 0.77 | CDC7 (0.57) | CDC7CYP1A2GRM4TRPM5SYK | |
| SCHEMBL20369249 | 0.77 | CDC7 (0.54) | CDC7CYP1A2GRM4TRPM5SYK | |
| SCHEMBL17608661 | 0.77 | GRM4 (0.48) | CDC7CYP1A2GRM4CCNCCDK8 | |
| SCHEMBL30728059 | 0.77 | CDC7 (0.64) | CDC7CYP1A2GRM4TRPM5SYK | |
| SCHEMBL8789947 | 0.76 | KMT2A (0.51) | CYP1A2GRM4NPC1MAPTRAB9A | |
| SCHEMBL14035668 | 0.76 | TRPM5 (0.59) | CDC7CYP1A2GRM4TRPM5SYK | |
| SCHEMBL15152275 | 0.76 | CDC7 (0.47) | CDC7CYP1A2GRM4TRPM5SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534343-B1 | Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-11-19 | — | — | EP | disclosed |
| US-5631270-A | COGNITION ACTIVATORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5424322-A | Substituted pyridinylamino-1h-indole derivatives | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-06-13 | — | — | US | disclosed |
| US-5328918-A | Psychological disorders, antiinflammatory agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5246947-A | Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-09-21 | — | — | US | disclosed |
| US-5229401-A | Cognition activators; Alzheimer's disease; psychological disorders,e.g obsessive-compulsive; antidepressants; topical antinflammatory agent; skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0534343-A1 | Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5185350-A | For Alzheimer*s, memory dysfunctions, antidepressants, antiinflammatory agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-02-09 | — | — | US | disclosed |